Introduction
Over the past few years, haircare science has circled around “bond-builders” that provide temporary fixes. They target one or two types of bonds, patching weak spots but never truly reversing damage. As customers become more aware of the necessity of a holistic approach to hair condition, they are recognizing the importance of addressing both mechanical resilience and surface aesthetics. Lipid Bond Technology has emerged as a key innovation delivering multidimensional restoration and protection for damaged hair.
Developed by Moonshot Biotech Singapore, Lipid Bond Technology is an exclusive US-patented platform. Utilizing plant triglycerides, Lipid Bond Technology created 369LAB Lipid Bond is a small molecular hair repair. By biomimicry, micro-sized lipid particles are engineered to be compatible with the hair fiber while replicating the structure and function of natural lipids.
Lipids were demonstrated to serve multiple functions in the structure of the hair fiber1,2. In addition to protecting against environmental factors and maintaining hair moisture, such as the 18-methyleicosanoic acid (18-MEA) layer 3, they also act as a cohesion agent in the medulla 4 and between the cuticle and cortex 5,6. Therefore, lipids were an element essential for preserving the smoothness, cohesion, and overall stability of the hair fiber 1,2.
We aimed to demonstrate the effectiveness of Lipid Bond Technology through high-quality scientific research and share the results with our customers. We published a study on Dermatology Research and Practice journals. Read the full study results in the Wiley Online Library.
This article is an overview of the study “Utilizing Lipid Bond Technology With Molecular Lipid Complex to Provide Lipid Treatment for Damaged Hair” of Lai et al 7, in 2025. We intend to provide a broad overview of lipid’s potential as a deep hair reconstruction treatment, as well as practical uses in hair care routines.
Experimental Design
Bleached hair was used as a damaged hair model to evaluate the restoration ability of 369LAB Lipid Bond. Each experiment was performed on 3 samples: natural hair, bleached hair, and bleached hair treated with 369LAB Lipid Bond.
369LAB Lipid Bond (70% of 369LAB Lipid Bond and 30% of water) was applied in the bleach treatment experiment. The treatment involved 15 minutes of soaking. For hair tensile assessment, a shampoo supplement with 369LAB Lipid Bond was used as the treatment and the control was a shampoo without added 369LAB Lipid Bond.
Evaluation of Particle Size
Particle size analysis confirmed that 369LAB Lipid Bond exists at an average particle size of 39.83 nm. Micro-sized particles allow the lipid molecules to penetrate through the hair layers and replenish the lipid bonds that are lost when the cuticle becomes damaged by chemical or environmental stress 8,9.
Evaluation of Lipid Content
When 369LAB Lipid Bond was used on bleached hair, the total lipid content increased by about 38% compared to untreated hair. Furthermore, the lipid content of bleached hair (8.81%) and natural hair (8.70%) was nearly identical, indicating that 369LAB Lipid Bond can penetrate deeply across several cell layers and restore lipid content to levels comparable to undamaged hair.
Figure. 2. SEM images of the bleached hair surface: left is before, and right is after treatment with 369LAB Lipid Bond. ( Lai et al.7, 2025)
Figure. 3. SEM images of the cross-sections of hair fiber;(a) Natural hair; (b) Bleached hair; (c) bleached hair after treatment with 369LAB Lipid Bond. ( Lai et al.7, 2025)
Evaluation of Structure Hair
Scanning Electron Microscopy (SEM) images show that after treatment with 369LAB Lipid Bond, the level of surface damage is significantly reduced (Figure 2). Observe on the surface of the cuticle, the damaged scales are smoothed and arranged tightly together, showing that the protective layer of the hair is restored and more durable (Figure 2(after))
Moreover, the inside structural damage is markedly improved when bleached hair after 369LAB Lipid Bond treatment (Figure 3). By penetrating deeply into the hair fiber, 369LAB Lipid Bond has filled in the pitting and restored the disordered structure of the bleached hair (Figure 3c). With 369LAB Lipid Bond, the bleached structure of the hair is brought back to a state that is close to natural, healthy hair.
Evaluation of Strength Hair
Finally, hair strength testing demonstrated a measurable increase in resistance to breakage. Hair treated with 369LAB Lipid Bond is more resistant to stress than untreated bleached hair, with approximately 37% more tensile strength.
This lipid enrichment contributes directly to improved firmness, as the structure becomes better anchored and more resilient since structure hair can better support tension. Together, these data illustrate that 369LAB Lipid Bond enhances not only the external appearance but also helps to recover the structure of the hair damage.7
Extended testing
Following the controlled laboratory assessments, a real-life hair test was performed to confirm the perceptible efficacy of the treatment on human hair. Observations in Figure 5 show that natural brown hair after using shampoo with 369LAB Lipid Bond is straighter, smoother, and no longer tangled (Figure 5a). For bleached hair, the shine and smoothness of the hair have improved, and the dry state has also been limited when using 369LAB Lipid Bond (Figure 5b). These findings show that 369LAB Lipid Bond is not only effective in restoring damaged hair structure but can also improve the aesthetics of the hair surface.
Conclusion
The results of these studies demonstrate that Lipid Bond Technology enhances the internal structure of hair by restoring cohesiveness within the hair fiber, which has potent restorative effects. Through this process, damaged hair can restore its natural strength, softness, and moisture content and return to its initial state of health.
Lipid Bond Technology transforms plant triglycerides into biomimetic lipids, giving them the ability to restore hair’s natural architecture and be biodegradable without environmental residue. Designed as a sustainable alternative to traditional silicone-based products, it features a solvent-free process that minimizes water, thermal energy, and electricity throughout the production process. This technology represents a new paradigm where molecular repair and sustainability coexist – rebuilding what was lost while protecting the planet that provides it.
In the future, further studies will focus on understanding the role and mechanism of 369LAB Lipid Bond under various conditions of use with various hair types, contributing to a comprehensive hair care solution.
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(2) Coderch, L.; Lorenzo, R. D.; Mussone, M.; Alonso, C.; Martí, M. The Role of Lipids in the Process of Hair Ageing. Cosmetics 2022, 9 (6), 124. https://doi.org/10.3390/cosmetics9060124.
(3) Coderch, L.; Alonso, C.; García, M. T.; Pérez, L.; Martí, M. Hair Lipid Structure: Effect of Surfactants. Cosmetics 2023, 10 (4), 107. https://doi.org/10.3390/cosmetics10040107.
(4) Csuka, D. A.; Csuka, E. A.; Juhász, M. L. W.; Sharma, A. N.; Mesinkovska, N. A. A Systematic Review on the Lipid Composition of Human Hair. Int. J. Dermatol. 2023, 62 (3), 404–415. https://doi.org/10.1111/ijd.16109.
(5) Takahashi, T.; Yoshida, S. A Highly Resistant Structure between Cuticle and Cortex of Human Hair. Int. J. Cosmet. Sci. 2017, 39 (3), 327–336. https://doi.org/10.1111/ics.12380.
(6) Méndez, S.; Manich, A. M.; Martí, M.; Parra, J. L.; Coderch, L. Damaged Hair Retrieval with Ceramide-Rich Liposomes. J. Cosmet. Sci. 2011, 62 (6), 565–577.
(7) Lai, N. H.; Dang, T. H. N.; Nguyen, T. T.; Phan, D. T. Q. Utilizing Lipid Bond Technology With Molecular Lipid Complex to Provide Lipid Treatment for Damaged Hair. Dermatol. Res. Pract. 2025, 2025 (1), 5385312. https://doi.org/10.1155/drp/5385312.
(8) Su, R.; Fan, W.; Yu, Q.; Dong, X.; Qi, J.; Zhu, Q.; Zhao, W.; Wu, W.; Chen, Z.; Li, Y.; Lu, Y. Size-Dependent Penetration of Nanoemulsions into Epidermis and Hair Follicles: Implications for Transdermal Delivery and Immunization. Oncotarget 2017, 8 (24), 38214–38226. https://doi.org/10.18632/oncotarget.17130.
(9) Patzelt, A.; Richter, H.; Knorr, F.; Schäfer, U.; Lehr, C.-M.; Dähne, L.; Sterry, W.; Lademann, J. Selective Follicular Targeting by Modification of the Particle Sizes. J. Controlled Release 2011, 150 (1), 45–48. https://doi.org/10.1016/j.jconrel.2010.11.015.
LABORIE derma-Hairscience applies Lipid Bond Technology throughout all product lines. This biotech and biomimetic delivers real, lasting repair—solving what traditional chemistry only conceals.
